Head & Neck Cancer (HNC): Curative Treatment with Radiotherapy and Chemotherapy

A pleasant lady, 53 years old with long standing hypertension, presented with dysphagia symptom for 3 months duration. She was diagnosed with base of tongue SCC, T2N2M0. Discussion in multidisciplinary team (MDT) meetings Surgery or definitive concurrent chemo-radiotherapy (CRT)? Surgeon want to operate, I want definitive concurrent CRT (happen all the time, ha3) Rationale? With…… Continue reading Head & Neck Cancer (HNC): Curative Treatment with Radiotherapy and Chemotherapy

Small Cell Lung Cancer (SCLC) – Deadliest Lung Cancer

Introduction Just some brief information (numbers) on small cell lung cancer (SCLC) before I jump into treatments for advanced SCLC. 20% of all lung cancers 95% are cigarette smokers (remaining I strongly believe is caused by second hand smoke (SHS) or environmental tobacco smoke (ETC) 90% of the tumor is located centrally 70-80% are extensive/…… Continue reading Small Cell Lung Cancer (SCLC) – Deadliest Lung Cancer

Living Longer: Advanced Breast Cancer (ABC) – HER2 over-expressed (II)

What happen when first-line treatment fails? In advanced or metastatic breast cancer, first-line treatment will fail after certain duration of time. This is because cancer cells developed resistance to the treatment and not because the treatment is ineffective. Life doesn’t end when first-line treatment fails. We just continue fighting the cancer with other effective second-line…… Continue reading Living Longer: Advanced Breast Cancer (ABC) – HER2 over-expressed (II)

News: Chemotherapy Kill Cancer Patients, Not Cancer?

The good intentions: The study published in reputable The Lancet Oncology journal emphasised the importance of proper selection of cancer patients for chemotherapy treatment, especially patients who are old or have poor performance status. The study also stressed on the importance of mortality review in order to improve clinical decision making (identifying patients who does…… Continue reading News: Chemotherapy Kill Cancer Patients, Not Cancer?

Living Longer: Advanced Breast Cancer (ABC) – HER2 over-expressed (I)

Introduction HER2 over-expression constitutes 20% of all breast cancer. Two different methods are being used to test for HER2 over-expression, immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) Immunohistochemistry (IHC); identifies HER2 expression on the cell surface, with a grading system of 0 to 3+ positive. tumors are classed as HER2-positive if they have a…… Continue reading Living Longer: Advanced Breast Cancer (ABC) – HER2 over-expressed (I)