Head & Neck Cancer (HNC): Curative Treatment with Radiotherapy and Chemotherapy

A pleasant lady, 53 years old with long standing hypertension, presented with dysphagia symptom for 3 months duration. She was diagnosed with base of tongue SCC, T2N2M0. Discussion in multidisciplinary team (MDT) meetings Surgery or definitive concurrent chemo-radiotherapy (CRT)? Surgeon want to operate, I want definitive concurrent CRT (happen all the time, ha3) Rationale? With…… Continue reading Head & Neck Cancer (HNC): Curative Treatment with Radiotherapy and Chemotherapy

Living Longer: Stage 4 Stomach Cancer (2nd line treatments)

Upon failure of first line treatment for stage 4 stomach cancer, patients with good performance status will benefit from second line treatments. Which agents, chemotherapy/ targeted therapy offer longest median OS in this setting? Second-line Treatments Docetaxel: median OS of 5.2 months (COUGAR-02) – 8.4 months (Lee, 2005) Paclitaxel: median OS of 7.8 months (CCOG…… Continue reading Living Longer: Stage 4 Stomach Cancer (2nd line treatments)

Living Longer: Stage 4 Stomach Cancer (1st line treatments)

In Malaysia, stomach cancer is the 8th most common cancer and most were detected at late stage; III (25%) and IV (50%). The median/ average overall survival for stage 4 stomach cancer is not high but there had been incremental increases in median overall survival throughout the years with chemotherapy and lately, with targeted therapy.…… Continue reading Living Longer: Stage 4 Stomach Cancer (1st line treatments)